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Hinge DYIRNC, SEQ ID NO: 3 MDCK Madin-Darby canine kidney Hinge was tested for its effects on dissociated hippocampal neurons and was found to have no effect on spinogenesis over a wide range of doses, thus indicating that Hinge and the HGF/c-Met system do not have a significant role in the basal spinogenesis seen in the cultured neurons (Figure 13A)

Figures 27 A & B indicate that those analogs that were previously found to block HGF dimerization were effective inhibitor of HGF/Met mediated cell scattering in MDCK cells, while those analogs with poor affinity for HGF were ineffective

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Toxicol Appl Pharmacol 261:1818 Steele ML, Fuller S, Patel M, Kersaitis C, Ooi L, Mnch G (2013) Effect of Nrf2 activators on release of glutathione, cysteinylglycine and homocysteine by human U373 astroglial cells

9 Moreover, all athletes who underwent PRP injection managed to return to training or daily sports activity